Publications

2026

Ganie RA, Biswas A, Sasi S, Devarakonda LP, Kale I, Mullick S, Siddappa G, Singh N, Gadadhar S & Sirajuddin M* (2026) Glutamylated vimentin proteoform identified by a synthetic binder links to epithelial-mesenchymal plasticity. bioRxiv (https://biorxiv.org/content/10.64898/2026.05.12.724742v1.full)

Mullick S, Kumar CS, Dey S, Koushik PB, Ganie RA, Mahanty S,  Sirajuddin M, Gadadhar S (2026) Tubulin glycylation regulates microtubule-protein interactions that are key for ciliary stability and trafficking bioRxiv (https://doi.org/10.64898/2026.03.26.714406)

2025

Jain P. K, Mahanty S, Henriot V, Janke C, Sirajuddin M, Dhandapany P. S. (2025) Tubulin tyrosine ligase variant perturbs microtubule tyrosination causing hypertrophy in patient-specific and CRISPR gene-edited iPSC-cardiomyocytes. JCI Insight. Aug 8;10(15):e187942. doi: 10.1172/jci.insight.187942. PMID: 40779454.

Syed, T.A., Ellwood, S., Dileep, D., Subha, S., Sirajuddin, M*., Siddiqi, K. (2025). Nuclear Patterning of Developing Cells in Murine Ventricular Heart Walls. In: Chabiniok, R., Zou, Q., Hussain, T., Nguyen, H.H., Zaha, V.G., Gusseva, M. (eds) Functional Imaging and Modeling of the Heart. FIMH 2025. Lecture Notes in Computer Science, vol 15673. Springer, Cham. https://doi.org/10.1007/978-3-031-94562-5_1

2024

Shukla AK, Banerjee M, Singh AK, Penmatsa A, Dutta S, Anand R, Sirajuddin M, Srivastava SS (2024). Cryo-EM research in India. Structure. 2024 Feb 1;32(2):113-119. doi: 10.1016/j.str.2024.01.002

2023

Bangera M., Dungdung A., Prabhu S., Sirajuddin M*. (2023) Doublet microtubule inner junction protein FAP20 recruits tubulin to the microtubule lattice. Structure Sep 29: S0969-2126(23)00333-7. (bioRxiv version https://www.biorxiv.org/content/10.1101/2022.11.25.517946v1)

Dileep D., Syed T. A., Sloan F.W. T., Dhandapany P.S., Siddiqi K., Sirajuddin M*. (2023) Cardiomyocyte orientation recovery at micron scale reveals long-axis fiber continuum in heart walls. The EMBO Journal e113288 Oct 4;42(19): e113288.

Syed, T.A., Wang, Y., Dileep, D., Sirajuddin, M., Siddiqi, K (2023). Ultrastructure Analysis of Cardiomyocytes and Their Nuclei. Functional Imaging and Modeling of the Heart. FIMH 2023. Lecture Notes in Computer Science, vol 13958. Springer, Cham. (https://doi.org/10.1007/978-3-031-35302-4_2)

Mendon N., Ganie R. A., Kesarwani S., Dileep D., Sasi S., Lama P., Chandra A., Sirajuddin M*. (2023) Nanobody derived using a peptide epitope from the Spike protein receptor-binding motif inhibits entry of SARS-CoV-2 variants J Biol Chem Volume 299, Issue 1, Jan 2023, 102732

2022

Jijumon A. S., Bodakuntla S., Genova M., Bangera M., Sackett V., Besse L., Maksut F., Henriot V., Magiera M. M., Sirajuddin M., Janke C (2022) Lysate-based pipeline to characterise microtubule-associated proteins uncovers unique microtubule behaviours Nature Cell Biology 2022 Feb;24(2):253-267. https://doi.org/10.1038/s41556-021-00825-4

2021

Lama P., Sirajuddin M. (2021) Initiation of ensemble kinesin-3 motility is regulated by the rigidity of cargo-motor attachment (bioRxiv version; https://www.biorxiv.org/content/10.1101/2021.12.02.470904v1)

2020

Kesarwani S., Lama P., Chandra A., Reddy P. P., Jijumon A. S., Bodakuntla S., Rao B. M., Janke C., Das R., Sirajuddin M. (2020) Genetically encoded live cell sensor for tyrosinated microtubules Journal of Cell Biology Oct 5;219(10): e201912107 (bioRxiv version; https://www.biorxiv.org/content/10.1101/2020.03.29.013250v1)

Kumari A., Kesarwani S., Javoor M. G., Vinothkumar K.R., Sirajuddin M.  (2020) Structural insights into filament recognition by cellular actin markers. The EMBO Journal Jul 15;39(14):e104006. Epub 2020 Jun 22 (bioRxiv version; https://www.biorxiv.org/content/10.1101/846337v1.abstract)

2015-2018

Rostovtseva T.K., Gurnev P.A., Hoogerheide D.P., Rovini A., Sirajuddin M., Bezrukov S.M. (2018) Sequence diversity of tubulin isotypes in regulation of the mitochondrial voltage-dependent anion channel. J Biol Chem. 2018 May 18. pii: jbc.RA117001569.

Sirajuddin M. (2017) Life as an early career researcher: interview with Minhaj Sirajuddin. Future Sci OA. Nov 1;4(2):FSO258. doi: 10.4155/fsoa-2017-0106.

McKenney R.J., Huynh W., Vale R.D., and Sirajuddin M. (2016) Tyrosination of alpha-tubulin controls the initiation of processive dynein-dynactin motility. The EMBO Journal Jun 1:35(11):1175-85. DOI: 10.15252/embj.201593071. (bioRxiv September 2015)

Nieh S.E., Madou M.R.Z., Sirajuddin M., Fregeau B., McKnight D., Lexa K., Strober J., Spaeth C., Hallinan B., Smaoui N., Pappas J.G., Burrow T.A., McConkie-Rosell A., Latibashvili M., Leshinsky-Silver E., Lev D., Blumkin L., Vale R.D., Barkovich A.J. and Sherr E.H. (2015) De novo mutations in KIF1A cause a syndrome of progressive encephalopathy and brain atrophy. Annals of Clinical and Translational Neurology May 1, 2015 DOI: 10.1002/acn3.198.

Publications before inStem

Sirajuddin M., Rice LM., and Vale RD. (2014). Regulation of microtubule motors by tubulin isotypes and posttranslational modifications Nature Cell Biology Apr;16(4) 335-44.

Sirajuddin M., Farkasovsky M., Zent E., and Wittinghofer A. (2009). GTP-induced conformational changes in septins and implications for function. PNAS 106(39):16592-7

Gasper R., Meyer S., Gotthardt K., Sirajuddin M., and Wittinghofer A. (2009) It takes two to tango: regulation of G proteins by dimerization. Nature Rev. Mol. Cell Biol 10:423-429

Sirajuddin M., Farkasovsky M., Hauer F., Kuhlmann D., Macara I.G., Weyand M., Stark H., and Wittinghofer A. (2007). Structural insight into filament formation by mammalian septins. Nature 449, 311-5

Prajapati R.S., Das M., Sreeramulu S., Sirajuddin M., Srinivasan S., Krishnamurthy V., Ranjani R., Ramakrishnan C., and Varadarajan R. (2007). Thermodynamic effects of proline introduction on protein stability. Proteins 66, 480-491.

Prajapati R.S., Sirajuddin M., Durani V., Sreeramulu S., and Varadarajan R. (2006). Contribution of cation-pi interactions to protein stability. Biochemistry 45, 15000-15010.